San Francisco 49ers wide receiver Ricky Pearsall endured a physically taxing afternoon in Sunday's win over the Tennessee ...

San Francisco would have a better chance at the No. 1 seed in the NFC playoffs if Seattle can pull off the victory at home.

The San Francisco 49ers finished their Week 15 contest with a 37-24 win over the Tennessee Titans at Levi's® Stadium.

After starting the season with a 10-4 record, the San Francisco 49ers take on the Indianapolis. Here's a look at the betting ...

An ESPN analyst believes the 49ers can make noise in the playoffs, but one fatal flaw could derail San Francisco's postseason ...

The 49ers defeated the Titans on Sunday, and 49ers head coach Kyle Shanahan was mic'd up for the matchup, which happened to ...

The Indianapolis Colts can't lose to the San Francisco 49ers, or their playoff hopes will fall into the abyss.

Monday, 8:15 p.m. EST, ESPN. BetMGM NFL odds: 49ers by 6. Against the spread: 49ers 9-5; Colts 8-6. Series record: Colts lead ...

See who's in and who's out for the Week 16 matchup between the San Francisco 49ers and Indianapolis Colts on December 22, ...

JJ Stankevitz from the Indianapolis Colts previews Week 16 "Monday Night Football", with one-on-one interviews featuring San ...

That's now four games won in a row by the San Francisco 49ers. They took care of business at home against the Tennessee ...

The Indianapolis Colts will enter their Monday Night matchup against the San Francisco 49ers as the home underdogs. At 8-6 on the season, the Colts have lost four consecutive games and five of six ...