Gout is a painful condition that can lead to joint damage and kidney problems. Gout crystals are the underlying cause of gout flare-ups. Gout crystals form when there is too much uric acid in your ...

The P2Y14 receptor, a G protein-coupled receptor activated by extracellular UDP-sugars, has emerged as a significant mediator in immune responses and inflammation. Although originally identified for ...

Gout is an intensely painful form of arthritis that affects over 8 million Americans. As our diets change to include more processed foods, and with the increase in popularity of high protein diets, ...

Jackson Professor of Clinical Medicine, Harvard Medical School; chief, Medical Services, Massachusetts General Hospital. Madan M. Singh, M.D. Research fellow in medicine, Harvard Medical School; ...

High uric acid concentration in the body (called hyperuricemia), leads to gout which causes joint inflammation, along with pain. The human body produces uric acid through purine breakdown, which ...