Saturation of TfR1 leads to the dissociation of Hfe and the binding of the alter to the TfR2, which in turn influences the binding of BMP6 to its receptors on the membrane. Increased liver iron ...
The need for regular blood transfusions, as well as underlying processes in MDS, can result in iron overload. If left untreated, excess iron can cause widespread damage to organs throughout the body.
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