Researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital (NRI) have identified and characterized two regions of DNA required ...

MeCP2 is a methyl DNA–binding transcriptional regulator that contributes to the development and function of CNS synapses; however, the requirement for MeCP2 in stimulus-regulated behavioral plasticity ...

This release is available in Spanish. A paper published online today in Molecular Cell proposes that Methyl CpG binding protein 2 (MeCP2) impacts the entire genome in neurons, rather than acting as a ...

A team of researchers has developed a strategy that allows them to identify potential treatments that would restore altered levels of MeCP2. Having twice the normal amount of the protein MeCP2, a ...

Rett syndrome is a rare devastating neurological disorder that primarily affects young girls and manifests as an impaired ability to walk and talk, along with characteristic 'hand-wringing' movements, ...

Only 300 people in the world have been diagnosed with a deadly genetic condition called MeCP2 duplication syndrome. MeCP2 duplication is a cureless neurological condition that typically affects males ...

Findings bolster the idea that the functions of this protein -- MeCP2 -- are more centered on nucleosomes, rather than other forms of DNA. One particular protein lies at the heart of brain development ...

Severe progressive neuropsychiatric disorders that include intellectual disability, autism spectrum disorders, motor dysfunction might be due to the abnormal levels of protein MeCP. In animal models, ...

In 1999, Dr. Huda Zoghbi and colleagues at Baylor College of Medicine identified the genetic cause of Rett syndrome (a neurological disorder that begins after birth) – MECP2 mutation. Too little of ...

The idea that natural variants of a single gene could substantially influence brain structure might blow your mind. But a study in this week’s PNAS Early Edition suggests just that. A research team ...

The methyl CpG binding protein 2 gene (MECP2) produces a protein of the same name, the level of which is critical for normal brain function. Mutations leading to protein under-expression cause Rett ...