Insulin is one of the most potent and pleiotropic hormones in the body, regulating a myriad of physiological processes. However, perhaps none is best studied as its role in regulating glucose ...

A new study focuses on the insulin receptor to understand its role in the development of type 2 diabetes mellitus, a metabolic disease with a major impact on global health. Insulin resistance precedes ...

Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high morbidity and mortality worldwide. In affected people, insulin is unable to ...

Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) acts as a negative regulator of the insulin signaling pathway by dephosphorylating both the insulin receptor (IR) and the insulin receptor ...

In a recent study published in the journal NPJ Metabolic Health and Disease, researchers hypothesize that the degradation of endogenously secreted insulin (as opposed to the commonly believed insulin ...

Glucose is the primary source of energy for many organisms, and the uptake of glucose is a critical process. Glucose is transported across the cell’s membrane and trapped by being phosphorylated. In ...

Taken together, our experimental paradigm in endothelial cells and VSMCs indicates that under normal conditions insulin is antiatherogenic. In endothelial cells, insulin stimulates NO production and ...

Adipocytes, also known as fat cells, come in three main types: white, brown, and beige. White fat cells are structurally quite simple, comprising a single fat molecule and a few organelles. The ...

The majority of patients with type 2 diabetes (T2D) have less than ideal metabolic control despite our greater understanding of the underlying pathophysiologic mechanisms of hyperglycemia and the ...