The Indianapolis Colts host the San Francisco 49ers on 'Monday Night Football' in NFL Week 16 action: Injury report.

Through 15 weeks, the 49ers have recorded just 16 sacks, which is the fewest in the league. It's six sacks fewer than the New York Jets and Baltimore Ravens who have the next fewest. While trading for Keion White and signing Clelin Ferrell has helped, San Francisco could still use more to give them a better shot of making a postseason run in 2025.

Find out how to watch the NFL Week 15 game between the San Francisco 49ers and Tennessee Titans, as well as the latest odds and updated injury report.

The 49ers and Rams faced off in the NFC title game in January of 2022 with Los Angeles punching their ticket to the Super Bowl. Matthew Stafford out dueled Jimmy Garoppolo, while Los Angeles scored 13 unanswered points in the fourth quarter to win.

The San Francisco 49ers are trending the right way from a health perspective entering a Week 16 showdown with the Indianapolis Colts.

NFL Week 16 picks, predictions, win probabilities for Buccaneers-Panthers, Jets-Saints, Vikings-Giants, Falcons-Cardinals, Steelers-Lions, more games.

Welcome to the Monday edition of the Pick Six newsletter! It is officially Thanksgiving week, but I can't even start to think about all the turkey I'm going to eat just yet and that's because we still have one more game to play in Week 12 and it's a ...

The Tennessee Titans will take on the San Francisco 49ers in Week 15 action. Here is one person that could give the Titans a boost.

The Carolina Panthers and San Francisco 49ers clash to wrap NFL Week 12 on Monday night at 8:15 p.m. ET. Bryce Young is surging for the Panthers, but it’s a “revenge game” for Christian McCaffrey against his former team. Young had three touchdowns in ...