ascopubs.org

Model Describing the Relationship Between Pharmacokinetics and Hematologic Toxicity of the Epirubicin-Docetaxel Regimen in Breast Cancer Patients

In the final pharmacokinetic model, interoccasion variability was estimated to be less than interindividual variability in the clearances for both drugs. The sum of the individual EPI and DTX areas ...
Nature

Population pharmacokinetics of moxifloxacin and its concentration–QT interval relationship modeling in Chinese healthy volunteers

Moxifloxacin (MX) is an 8-methoxyquinolone antimicrobial drug, which is often used as a positive control in thorough QT (TQT) studies. In the present study we established the population ...
ascopubs.org

A rational approach to dose optimisation of pembrolizumab using cost analysis and pharmacokinetic modelling and simulation.

Responses in patients with BRAF V600-mutant metastatic melanoma receiving anti-PD1/PDL1 therapy alone or combined with BRAF inhibitors.
Nature

Linking a dermal permeation and an inhalation model to a simple pharmacokinetic model to study airborne exposure to di(n-butyl) phthalate

Six males clad only in shorts were exposed to high levels of airborne di(n-butyl) phthalate (DnBP) and diethyl phthalate (DEP) in chamber experiments conducted in 2014. In two 6 h sessions, the ...
The American Journal of Managed Care

Model Suggests Body Weight Affects Dupilumab Pharmacokinetics in Patients With Asthma

Although body weight affected pharmacokinetics, the investigators said dosing adjustments based on weight were not warranted. A new report shows the pharmacokinetic properties of Dupixent (dupilumab) ...
National Academies of Sciences%2c Engineering%2c and Medicine

Human Biomonitoring for Environmental Chemicals

Physiologically based pharmacokinetics (PBPK), as the name implies, is a special branch of pharmacokinetics where physiology and anatomy of the animal or human body, as well as the biochemistry of the ...