All eukaryotic cells contain protein complexes called proteasomes. Proteasomes maintain the concentration of proteins in cells as well as disposing of unneeded or damage proteins. The process of ...
The proteasome is a major proteolytic machine that regulates cellular proteostasis through selective degradation of ubiquitylated proteins. As the maintenance of protein homeostasis is essential to ...
Researchers at National Taiwan University have uncovered, for the first time at atomic resolution, how the human proteasome recognizes branched ubiquitin chains. Their finding reveals a multivalent ...
For more than two decades, medical providers have treated multiple myeloma (MM) with proteasome inhibitors (PIs). This important drug therapy has helped improve survival rates of people with MM.
Short-Term Efficacy of Methylphenidate: A Randomized, Double-Blind, Placebo-Controlled Trial Among Survivors of Childhood Cancer To determine the maximum-tolerated dose, dose-limiting toxicity (DLT), ...
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Experimental model enables study of how protein complex influences mitochondrial function
A study by the Center for Redox Processes in Biomedicine (Redoxoma) led by Marilene Demasi from the Butantan Institute (São Paulo, Brazil) presents a valuable new experimental model for investigating ...
Researchers from Harvard Medical School (HMS) have discovered how a protein called midnolin plays a key role in degrading many short-lived nuclear proteins. Their study showed that midnolin acts by ...
Booster Therapeutics is developing a novel therapeutic approach that aims to combat the accumulation of deviant proteins in cells, which are a major driver of Parkinson’s and other complex diseases ...
A study by the Center for Redox Processes in Biomedicine (Redoxoma) led by Marilene Demasi from the Butantan Institute (São Paulo, Brazil) presents a valuable new experimental model for investigating ...
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