RAB GTPases and the related ADP-ribosylation factors (ARFs) comprise the largest family of small GTPases, with over 60 members found in humans. Phosphoinositides, which are phosphorylated forms of ...

The binding epitope in Rbsn(728–784) is divided into two hydrophobic pockets by a polar ridge bisecting the long axis. One pocket buries invariant residues (Phe 42 and Trp 75) from the switch I and ...

Researchers have uncovered the mechanism that switches off the cell transport regulating proteins. They were able to resolve in detail how the central switch protein Rab is down-regulated with two ...

Rab GTPases localise to distinct cellular organelles and regulate all stages of intracellular membrane trafficking in eukaryotic cells. Their activity state and functional effects are controlled and ...