Researchers at USF Health have discovered a new way opioid receptors can work that may lead to safer pain medications. Their findings show that certain experimental compounds can amplify pain relief ...

Given how profound an influence opioids have on the world – for better or worse – scientists know surprisingly little about how these drugs actually work. A recent study led by researchers from ...

New research reveals previously unknown ways opioid receptors can function, opening the door to safer pain treatments.

Scientists are racing to redesign how powerful painkillers work, aiming to keep the relief that opioids provide while ...

Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. Researchers have taken a ...

Scientists have known for decades that opioids relieve pain by binding to molecular switches in the brain called mu-opioid (pronounced "mew-opioid") receptors. What they didn't know - until now - was ...

Neuropeptide FF (NPFF) is an endogenous peptide that plays a critical role in modulating opioid receptor function. Its dual capacity to influence both opioid-induced analgesia and tolerance has ...

MONMOUTH JUNCTION, N.J., Jan. 08, 2026 (GLOBE NEWSWIRE) -- Tris Pharma, Inc. (Tris), a commercial-stage biopharmaceutical company, today announced the acceptance of its peer-reviewed article "The ...

For decades, opioids have been the blunt instrument of modern pain care, powerful enough to quiet severe suffering yet risky ...