Figure 1: Overall structure of the E. coli DNA topoisomerase III–ssDNA complex. The mode of ssDNA binding that we observe is representative of the pre-cleavage or post-religation state of the enzyme ...
Topoisomerase II-α (topo IIα) is the key target enzyme for the topoisomerase inhibitor class of anti-cancer drugs. In normal cells, topo IIα is expressed predominantly in the S/G2/M phase of the cell ...
A topoisomerase enzyme discovered more than a decade ago in an archaeal microorganism turns out to be distinct, both structurally and mechanistically, from any other known topoisomerase. Only four ...
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